MC-Val-Cit-PAB(m-PEG8)-Exatecan m-peg4 [O-]C(=O)C1=CC(=CC=C1C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)C(=O)NCC#C Purity (HPLC): ≥ 95%

[O-]C(=O)C1=CC(=CC=C1C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)C(=O)NCC#C Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

Product Name Thalidomide-O-PEG2-C2-amine HCl Synonyms Thalidomide-4'-O-PEG2-C2-amine HCl CAS Number 1957236-10-0 Related CAS Molecular Formula C19H24ClN3O7 Molecular Weight 441

Product Name Lenalidomide-PEG3-propargyl Synonyms Lenalidomide-4'-PEG3-propargyl CAS Number n/a Related CAS Molecular Formula C22H27N3O6 Molecular Weight 429

Product Name DBCO-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4)-MMAE Synonyms CAS Number Related CAS Molecular Formula C100H150N14O25 Molecular Weight 1948

Product Name Pomalidomide-CO-C4-alkyne Synonyms Pomalidomide-4'-CO-C4-alkyne CAS Number n/a Related CAS Molecular Formula C20H19N3O5 Molecular Weight 381

MC-Val-Cit-PAB(m-PEG8)-Exatecan m-peg4 [O-]C(=O)C1=CC(=CC=C1C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)C(=O)NCC#C Purity (HPLC): ≥ 95%SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures,